Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on fragrance raw materials: Benzophenone
Author:
Opdyke DLJ
Year:
1979
Bibliographic source:
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. Volume(issue)/page/year: 11,873,1979
Reference Type:
other: Authoritative data base
Title:
GCID :38768
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource);Food and Cosmetics Toxicology. Vol. 11, Pg. 873, 1973

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from publication
GLP compliance:
not specified
Test type:
other: no data
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 535 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acute dermal toxicity (LD50) value of benzophenone to rabbit on the basis of mortality was obtained at dose concentration 3535 mg/kg bw .This value indicate that benzophenone is non toxic to rabbit by dermal route.
Executive summary:

Acute dermal toxicity (LD50) value of benzophenone to rabbit on the basis of mortality was obtained at dose concentration 3535 mg/kg bw .This value indicate that benzophenone is non toxic to rabbit by dermal route.