2-(2-methylpropoxy)ethanol

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

February 12, 1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

other: Tanii and Hashimoto (1982)

Version / remarks:

Tanii, H. and Hashimoto, K. (1982). Structure-toxicity relationship of acrylates and methacrylates. Toxicology Letters, 11, 125 - 129.

Deviations:

no

Principles of method if other than guideline:

N-octanol was saturated with distilled water and distilled water was saturated with n-octanol. The test substance was dissolved in distilled water at <1.0 mM. Within sealed tubes the water and n-octanol organic phase were mixed at a volume ratio of 5 ml and 1.0 ml, respectively, before being placed on a mechanical shaker for 1 hour and centrifuged for 30 minutes at 2500 revolutions per minute. Gas-liquid chromatography (Hitachi Model 163 gas chromatograph with flame ionisation detector) was used to analyse the quantity of 2-(2-methylpropoxy)ethanol in the water phase. The temperature of the gas chromatography glass column and detector was 160 and 180 °C, respectively, and the carrier gas was N2. The column was packed with polyethylene glycol 20 M. The concentration of 2-(2-methylpropoxy)ethanol) in the water phase was used to determine that present inn-octanol. The following equation was used to calculate the partition coefficient for the registered substance:
 
P = Concentration of ester in-octanol / Concentration of ester in water

GLP compliance:

no

Type of method:

estimation method (solubility ratio)

Partition coefficient type:

octanol-water

Analytical method:

other: Gas-liquid chromatography (Hitachi Model 163)

Key result

Type:

log Pow

Partition coefficient:

0.75

Remarks on result:

other: Mean of three determinations / Undertaken at room temperature

Details on results:

2-(2-methylpropoxy)ethanol) was clearly seperated from the organic n-octanol phase that was dissolved in distilled water.

Conclusions:

The octanol-water partition coefficient for 2-(2-methylpropoxy)ethanol was calculated to be log Kow = 0.75 following analyses by gas-liquid chromatography.

Executive summary:

An experiment was undertaken by Tanniet al. (1992) to determine the octanol-water partition coefficient of 2-(2-methylpropoxy)ethanol and thirteen other ethylene glycol ethers as part of a study evaluating structure-toxicity relationships. The estimation (solubility ratio) methodology followed was according to that outlined by Tanni and Hashimoto (1982) and involved analyses by gas-liquid chromatography with flame ionisation detection and a glass column. Under the conditions of the experiment, 2-(2-methylpropoxy)ethanol was reported to be evidently separated from the organic (n-octanol) phase that had been dissolved in water. Following analyses, a log Kow of 0.75 was determined for 2-(2-methylpropoxy)ethanol.

Description of key information

Following analyses by gas-liquid chromatography, a log Kow of 0.75 was determined for the partition coefficient of 2-(2-methylpropoxy)ethanol, i.e. the ratio of the concentrations of the registered substance present in water and an organic (n-octanol) phase.

Key value for chemical safety assessment

Log Kow (Log Pow):

0.75

at the temperature of:

20 °C

Additional information

The key value was obtained from a study that was considered to be well documented and have met generally accepted scientific principles. The result was published in a reputable scientific journal (Archives of Toxicology) and the procedure, although not guideline (e.g. OECD) or a national standard method, was published by Toxicology Letters (Tanni and Hashimoto 1982). A Klimisch score of 2 (reliable with restrictions) has subsequently been recommended for the endpoint value and it is suitable for chemical safety assessment.