Propylidynetrimethanol

Short-term toxicity to fish

Description of key information

The 96-h LC50 of trimethylolpropane to the bleak (Alburnus alburnus) was determined to be greater than 1000 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

mg/L

Additional information

Key study:

The acute toxicity of trimethylolpropane to the bleak (Alburnus alburnus) was determined in a static test with brackish water (7‰, pH 7.8) and with an exposure duration of 96 h. Six different concentrations, not further specified, were tested. The 96-h LC50 was determined to be greater than 1000 mg/L as reported by Bengtsson and > 10,000 mg/L as reported by Linden (based on nominal concentrations). The study satisfies the guideline requirements for an acute toxicity study with fish.

Reference: Bengtsson & Tarkpea, 1983, Linden et al., 1979

Supporting studies:

The acute toxicity of trimethylolpropane was tested with the freshwater species Oryzias latipes under semi-static conditions following an OECD guideline. The 96 h LC50 was determined to be greater than 1000 mg/L.

Reference: EA Japan, >=1994 (Reliability 2)

The acute toxicity of trimethylolpropane was tested in a static acute test on Cyprinodon variegatus. A 96 h LC50 of 14,400 mg/L was determined with a 95% confidence interval of 11,498 - 18,035 mg/L. (Reliability 4)

Reference: Walton, 1989

The toxicities of trimethylolpropane to marine and freshwater fish seem therefore to be comparable. Since the publications by Bengtsson & Tarkpea and Linden et al. are more detailed than the data in the SIDS on the study from EA Japan, they were chosen as key study.

Further studies:

In a 96 h acute toxicity study, Danio rerio were exposed to trimethylolpropane at nominal concentrations of 10, 50 and 100 mg/L under static conditions. The 96-h LC0 was 100 mg/L. An LC50 > 100 mg/L may be derived from this result. The reliability of the result may not be assigned, as only a few data are available.

Reference: Bayer, 1982

In a 96-h acute toxicity study, Danio rerio were exposed to trimethylolpropane at nominal concentrations of 10 and 100 mg/L under static conditions.  The substance was dissolved in methanol. The 96 h LC0was 100 mg/L. An LC50 > 100 mg/L may be derived from this result. Only raw data are available, only 2 test concentrations were tested and a vehicle was used.The result is therefore not considered to be reliable.

Reference: Bayer, 1984

In a 48-h static acute toxicity study, Leuciscus idus were exposed to trimethylolpropane at nominal concentrations of 1000 mg/L under static conditions.  The 48-h NOEC was 1000 mg/L. A LC50>= 1000 mg/L may be derived from this result. It is a screening test: only one test concentration was tested with 2 animals per vessel, exposure period 48h instead of 96h. The result is therefore not considered to be reliable.

Reference: Bruns, 1973