Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: data from handbook
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary citation: data from handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
Polyhydric Alcohols
Author:
Mellan J
Year:
1962
Bibliographic source:
Spartan Books, Washington, DC, 1961 p 181 cited by Weber and Daley: other polyhydric alcohols in Encyclopedia of Chemical Technology (ed. Kirk-Othmer) Vol 1, 778-789

Materials and methods

Study type:
other: data from handbook
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
data from handbook
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propylidynetrimethanol
EC Number:
201-074-9
EC Name:
Propylidynetrimethanol
Cas Number:
77-99-6
Molecular formula:
C6H14O3
IUPAC Name:
2-ethyl-2-(hydroxymethyl)propane-1,3-diol
Details on test material:
Trimethylolpropan os a white solid

Method

Type of population:
other: data from handbook
Subjects:
- Number of subjects exposed: 200 humans
Ethical approval:
not specified
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
patch test (no further information)
Examinations:
observation of skin reaction (no further information)
Medical treatment:
no data

Results and discussion

Clinical signs:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
Results of examinations:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
Effectivity of medical treatment:
no data
Outcome of incidence:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.

Any other information on results incl. tables

Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.

Applicant's summary and conclusion

Executive summary:

Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer (Mellan 1962)