Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: data from handbook
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary citation: data from handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
Polyhydric Alcohols
Author:
Mellan J
Year:
1962
Bibliographic source:
Spartan Books, Washington, DC, 1961 p 181 cited by Weber and Daley: other polyhydric alcohols in Encyclopedia of Chemical Technology (ed. Kirk-Othmer) Vol 1, 778-789

Materials and methods

Study type:
other: data from handbook
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
data from handbook
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propylidynetrimethanol
EC Number:
201-074-9
EC Name:
Propylidynetrimethanol
Cas Number:
77-99-6
Molecular formula:
C6H14O3
IUPAC Name:
2-ethyl-2-(hydroxymethyl)propane-1,3-diol
Details on test material:
Trimethylolpropan os a white solid

Method

Type of population:
other: data from handbook
Subjects:
- Number of subjects exposed: 200 humans
Ethical approval:
not specified
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
patch test (no further information)
Examinations:
observation of skin reaction (no further information)
Medical treatment:
no data

Results and discussion

Clinical signs:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
Results of examinations:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
Effectivity of medical treatment:
no data
Outcome of incidence:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.

Any other information on results incl. tables

Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.

Applicant's summary and conclusion

Executive summary:

Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer (Mellan 1962)