Registration Dossier
Registration Dossier
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EC number: 201-074-9 | CAS number: 77-99-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: data from handbook
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary citation: data from handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Polyhydric Alcohols
- Author:
- Mellan J
- Year:
- 1 962
- Bibliographic source:
- Spartan Books, Washington, DC, 1961 p 181 cited by Weber and Daley: other polyhydric alcohols in Encyclopedia of Chemical Technology (ed. Kirk-Othmer) Vol 1, 778-789
Materials and methods
- Study type:
- other: data from handbook
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- data from handbook
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylidynetrimethanol
- EC Number:
- 201-074-9
- EC Name:
- Propylidynetrimethanol
- Cas Number:
- 77-99-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Details on test material:
- Trimethylolpropan os a white solid
Constituent 1
Method
- Type of population:
- other: data from handbook
- Subjects:
- - Number of subjects exposed: 200 humans
- Ethical approval:
- not specified
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- patch test (no further information)
- Examinations:
- observation of skin reaction (no further information)
- Medical treatment:
- no data
Results and discussion
- Clinical signs:
- Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
- Results of examinations:
- Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
- Effectivity of medical treatment:
- no data
- Outcome of incidence:
- Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
Any other information on results incl. tables
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer.
Applicant's summary and conclusion
- Executive summary:
Patch tests performed on 200 humans indicate that trimethylolpropane is neither a primary skin irritant nor a skin sensitizer (Mellan 1962)
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