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Registration Dossier
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EC number: 201-074-9 | CAS number: 77-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP was not implemented as were official testing guidelines at the time of study conduct. Study meets generally accepted scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- Male and female Wistat rats were fed with 0, 0.03, 0.1, 0.3, and 1 % TMP in diet and were observed for general appearance and behaviour. Growth, food intake hematology clinical chemistry data and data from, urinalysis were noted. At week 14 all rats were sacrificed and examined grossly and different organs were weighed ; Histopathological examinatiom was carried out.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Propylidynetrimethanol
- EC Number:
- 201-074-9
- EC Name:
- Propylidynetrimethanol
- Cas Number:
- 77-99-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Details on test material:
- No data on purity but infra red spectrum is shown.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 50 male and 50 female weanling rats from the CIVO-colony were divided according to body weights over 5 groups of 10 males and 10 females each, and fed on stock diet with trimethylolpropane added at levels of 0, 0.03, 0.1, 0.3 and 1.0%..
the animals were housed in screen bottom cages (5 to a cage) in a room of constant temperature at ca. 24°C.
Food and tap water were constantely available.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: test substance was mixed with diet
- Details on exposure:
- the test compound was thoroughly mixed into the diet by means of a mechanical blender.
the diets were freshly prepared once a fortnight and stored at room temperature - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 d
- Frequency of treatment:
- daily
- Duration of test:
- 90 d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.03,0.1, 0.3, or 1 % (corresponding to 20, 67, 200. pr 667 mg/kg bw/day)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, plain diet
- Details on study design:
- post exposure period: no
- Statistics:
- yes, but method not mentioned
Results and discussion
Observed effects
female rat:
at 1% TMP in diet the average relative weight of ovars were significantly increases , but there was no pathological or histopathological correlate
male rats:
no findings were reported
Any other information on results incl. tables
For further details : see section 7.51 Repeated dose toxicity: oral
Applicant's summary and conclusion
- Executive summary:
After feeding of trimethylolpropane to young male and female Wistar rats at 0, 0.03, 0.1, 0.3, 1.0 % in diet (corresponding to 20, 67, 200 or 667 mg/kg bw/d) for three months no adverse effects on reproductive organs of male Wistar rats were found; the significantly increased average relative weight of ovars in female rats occurred at clear toxic dose and was without pathological or histopathological correlate. Thus, this finding cannot be evaluated as specific effect due to reproductive toxicity.
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