Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-560-9
CAS number: 107934-68-9
Skin sensitisation (equivalent to OECD 406):
of the skin sensitization potential of the test substance using the
guinea-pig according to OECD 406 guideline and GLP principles. No signs
of ill health or toxicity were recorded.
injections: Necrosis was recorded at sites receiving FCA in test and
control animals. Slight irritation was seen in test animals at sites
receiving the 2.5% test substance in Alembicol D and similar signs of
irritation were observed in control animals receiving Alembicol D.
application: Slight erythema was observed in test animals following
topical application with the 70% test substance in Alembicol D and
similar signs of irritation were seen in the controls.
were no dermal reaction seen in any of the test or control animals.
on the results, the substance did not produce evidence of skin
sensitization in any of the twenty test animals.
The skin sensitising potential of
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline) (CAS 107934-68-9) was
evaluated in a guinea pig maximisation test performed according to OECD
406 (Parcell and Healing, 1991). 20 female guinea pigs in the test group
and 10 females in the control group were induced by intradermal and
epicutaneous exposure to the test substance. Intradermal induction was
performed with 2.5% test solution, and epicutaneous induction was
performed with 70% test solution. Skin reactions (necrosis) were
observed after intradermal induction at application sites receiving FCA.
In addition, slight irritation was observed at sites receiving 2.5%
(intradermal induction) test substance in Alembicol D. Slight erythema
were observed following topical induction. The challenge was performed
by open epicutaneous exposure to a 25% and 50% formulation of test
substance in Alembicol D. The animals in the treatment group and the
control group did not show any signs of a sensitising effect at the
reading time points (24, 48, and 72 h after challenge). In conclusion
0/10 and 0/20 animals of the control and test group showed any reaction
after the challenge period, thus indicating that the test substance is
not sensitising under the conditions of the test.
Justification for selection of skin sensitisation endpoint:
There is only one study available.
No data available.
Justification for selection of
respiratory sensitisation endpoint:
The study is not required according to Annex VII - X of Regulation
(EC) No 1907/2006.
The available data on skin
sensitisation of 4,4´-(9H-fluoren-9 -ylidene)bis(2 -chloroaniline) do
not meet the criteria for classification according to Regulation (EC)
1272/2008, and are therefore conclusive but not sufficient for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again