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EC number: 407-560-9
CAS number: 107934-68-9
NOAECcorr = NOAELoral*(1/0.38 m³/kg bw/day)*(ABSoral-rat/ABSinh-human)*(6.7 m³ (8h)/10 m³ (8h)) = 1000 mg/kg bw/day*(1/0.38 m³/kg bw/day)*0.67*(1/1) = 1763.12 mg/m³. It is assumed that oral absorption rate is 100% of that of inhalation absorption. ABSoral-rat=oral absorption rate in rats, ABSinh-human=inhalation absorption rate in humans.
NOAELcorr = NOAELoral*(ABSoral-rat/ABSdermal-human) = (1000 mg/kg bw/day)*(1/0.01) = 100000 mg/kg bw/day. It is assumed that the dermal absorption rate is <1% of that of the oral absorption according to ECHA CSA Guidance Chapter R.7c Figure R.7.12-5 and QSAR calculation with DermWinTM. ABSoral-rat=oral absorption rate in rats, ABSdermal-human=dermal absorption rate in humans.
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