4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline)

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

03-26 May 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Also according to GLP

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Principles of method if other than guideline:

Sieve, Cascade Impactor

GLP compliance:

yes (incl. QA statement)

Remarks:

2005-11-21

Type of method:

cascade impaction

Type of distribution:

mass based distribution

No.:

#1

Size:

< 100 µm

Distribution:

91.7 %

Remarks on result:

other: Sieve

No.:

#2

Size:

< 10 µm

Distribution:

4.08 %

No.:

#3

Size:

< 5.5 µm

Distribution:

0.312 %

Screening method:

Sieve aperture size (µm)	100
Mass of test material transferred to sieve (g)	10.56
Mass of test material passed through sieve (g)	9.68
Test material less than sieve aperture size (%)	91.7

Definitive test (cascade impactor method):

Determination 1

Cup number	Particle size cut points (µm)	Cumulative Mass of Test Material (g)	Cumulative Amount of Test Material (%)
2	10.0	0.0843	2.853
3	5.5	0.0048	0.162
4	2.4	0.0005	1.69x10^-2
5	1.61	0.0000	0.000
Filter	0.307	0.0000	0.000

Dtermination 2

Cup number	Particle size cut points (µm)	Cumulative Mass of Test Material (g)	Cumulative Amount of Test Material (%)
2	10.0	0.1322	4.42
3	5.5	0.0142	0.474
4	2.4	0.0028	9.35x10^-2
5	1.61	0.0018	6.01x10^-2
Filter	0.307	0.0015	5.01x10^-2

Determination 3

Cup number	Particle size cut points (µm)	Cumulative Mass of Test Material (g)	Cumulative Amount of Test Material (%)
2	10.0	0.1728	4.97
3	5.5	0.0104	0.299
4	2.4	0.0007	2.01x10^-2
5	1.61	0.0001	2.88x10^-3
Filter	0.307	0.0001	2.88x10^-3

Too few particles were of size less than 10.0 µm to allow accurate assessmnet of mass median aerodynamic diameter.

Conclusions:

Too few particles were of size less than 10.0 µm to allow accurate assessment of mass median aerodynamic diameter.

Executive summary:

Particle size data have been acquired following the OECD Guideline 110 and GLP.

Inhalable particles (< 100 µm): 91.7%

Thoracic particles (< 10 µm): 4.08%

Respirable particles (< 5.5 µm): 0.312%

Description of key information

91.7% < 100 µm
4.08% < 10 µm
0.312% < 5.5 µm

Additional information

The particle size distribution (granulometry) of the substance was determined using sieve and cascade impactor. The method applied is considered equivalent to OECD Guideline 110.