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EC number: 407-560-9
CAS number: 107934-68-9
There are valid acute studies available for
three trophic levels for 4,4´-(9H-fluoren-9-ylidene)bis(2-chloroaniline)
(CAS No. 107934-68-9). No toxic effects occurred up to the highest test
substance concentration for algae, daphnia and fish.
In addition to these acute studies a long
term test on Daphnia magna (OECD 211) is available for this substance.
Due to the low water solubility of the test item, a Water Soluble
Fraction (WSF) was prepared at a loading rate of 5.0 mg/L and used as
the highest concentration. Lower test concentrations were prepared by
diluting the highest concentration in test medium. The actual
concentrations measured in the undiluted WSF at the start of each
refreshment period were at the level of 1.0 to 2.0 µg/L. Significant
reduction of reproduction was found at average measured exposure
concentrations of 14 ng/L and higher.
4,4’-(9H-fluoren-9-ylidene)bis(2-chloroaniline) did not affect
reproduction of Daphnia magna at 6.8 ng/L after 21 days of exposure
(NOEC). Therefore, in contrast to results of acute aquatic
ecotoxicity tests, adverse effects are observed within the substances
As given in the Guidance on
Information Requirements and Chemical Safety Assessment R.11
PBT-assessment (ECHA 2014) a NOEC < 0.01 mg/L triggers the T (toxicity)
criterion. As the NOEC for
4,4´-(9H-fluoren-9-ylidene)bis(2-chloroaniline) (CAS No. 107934-68-9) is
considerably lower, the substance is regarded as toxic (T).
A further test on the toxicity to
activated sludge is available for this substance (OECD 209) with no
observed effects at 1000 mg/L (nominal) on respiration.Therefore,
the inhibition of the degradation activity of activated sludge is not
anticipated when introduced in appropriate low concentrations.
It should be noted, that due to the strictly
self-contained use of the substance, environmental exposure is unlikely.
The environmental exposure assessment performed for this substance (see
CSR attached to IUCLID section 13) shows that indeed the Risk
Characterization Ratio (i. e. PEC/PNEC ratio) in the aquatic compartment
is < 1 and therefore, under the current exposure conditions, 4,4´-(9H-fluoren-9-ylidene)bis(2-chloroaniline)
(CAS No. 107934-68-9) does not pose a risk to aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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