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Registration Dossier
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EC number: 500-051-3 | CAS number: 26780-96-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to scientifically accepted method; old study with limited documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not applicable
- Remarks:
- Study conducted 1974; limited documentation
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
- EC Number:
- 500-051-3
- EC Name:
- 1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
- Cas Number:
- 26780-96-1
- Molecular formula:
- (C12H15N)x
- IUPAC Name:
- 2,2,4-trimethyl-1,2-dihydroquinoline
- Details on test material:
- Flectol H; no further data on purity
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 4, 24, 48, 72 and 168 hours after treatment
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 and 168 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72, 168 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Other effects:
- No effects mentioned in report
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The test compound was not irritating to the skin in an study equivalent to OECD TG 404 with 6 rabbits dosed with 500 mg TMQ.
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