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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; endpoint record transferred from IUCLID 4

Data source

Reference
Title:
No information
Author:
Telford, I.R. et al., Am. J. Anat. 110, 29-36 (1962)

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
EC Number:
500-051-3
EC Name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
Cas Number:
26780-96-1
Molecular formula:
(C12H15N)x
IUPAC Name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
Constituent 2
Reference substance name:
quinoline, 1,2-dihydro-2,2,4-trimethyl-, homopolymer
IUPAC Name:
quinoline, 1,2-dihydro-2,2,4-trimethyl-, homopolymer

Test animals

Species:
rat
Strain:
other: Walter Reed-Carworth Farms
Sex:
female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
Exposure period: 22 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
250 mg/animal, total dose (= ca. 56.8 mg/kg bw/d)
Basis:

Control animals:
yes

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no maternal toxicity, no increase in the resorptions-rate

Applicant's summary and conclusion