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EC number: 500-051-3
CAS number: 26780-96-1
PBT AND VPVB ASSESSMENT
The assessment of PBT and vPvB is
performed by comparison of the relevant intrinsic properties of TMQ with
the criteria of the REACH regulation (Annex XIII) as shown inTable
and vPvB criteria and the corresponding properties ofTMQ
Half-life in marine water > 60 d, or half-life in fresh- or estuarine water > 40 d, or half-life in marine sediment > 180 d, or half-life in fresh- or estuarine water sediment > 120 d, or half-life in soil > 120 d
Half-life in marine, fresh or esturarine water > 60 d, or half-life in marine, fresh or esturarine sediment > 180 d, orhalf-life in soil > 180 d
Not readily biodegradable(Bayer AG, 2000)
Not inherently biodegradable with adapted bacteria (Monsanto, 1979)
BCF > 2000
BCF > 5000
Measured BCF of TMQ <2000 (MITI, 1995)
Long-term NOEC for marine or freshwater organisms < 0.01 mg/L
72h-EL0 (algae) ≥ 100mg/L(Bayer AG, 2000)
48h-EL50 (daphnia) = 56mg/L (Bayer AG, 2000)
Not classified as CMR
Other evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC
Not classified as T, R48, or Xn, R48 according to Directive 67/548/EEC
of PBT/vPvB Properties - Comparison with the Criteria of Annex XIII
TMQ is not readily biodegradable with no
biodegradation observed in 28 days (Bayer AG, 2000) and not inherently
biodegradable with only 1 % biodegradation observed in 35 days exposure
to adapted bacteria (Monsanto, 1979); and hence TMQ is concluded as
provisionally persistent under environmental conditions.
The BCF of 108 - 1300 for TMQ was
observed with Cyprinus carpio as test organism within 8 weeks (MITI,
1995). According to this result, TMQ can be considered as
bioaccumulative; but does not fulfill B criterion.
The most sensitive acute
toxicity of TMQ is to Daphnia with an EL50 of 56 mg/L based on water
accommodated fraction (Bayer AG, 2000), which is much higher than 0.1
mg/L and hence presumably not toxic. The only chronic EL0 was determined
in a 72h algal toxicity study as ≥ 100 mg/L (Bayer AG, 2000), which is
also much higher than 0.01 mg/L and hence support the same conclusion
that TMQ is not toxic.
Furthermore, the substance
is not classified as carcinogenic, mutagenic or toxic for reproduction.
For these reasons, the substance does not meet the T-criterion.
Summary and overall
Conclusions on PBT or vPvB Properties
According to the information
summarized above, only P criteriion is fulfilled but not Band T
criteria; and hence TMQ is not PBT or vPvB substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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