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EC number: 500-051-3
CAS number: 26780-96-1
Starting point: NOAEL 12 mg/kg/day; chronic 2 years study in rats;
target organ: liver and adrenal
Allometry: 4 (rat-humans)
Additional uncertainty: 1 (there is evidence that inter-species
differences are covered in general by allometric scaling and no
additional factor for remaining difference is necessary (Escher and
Mangelsdorf 2010, ECETOC Report 2003, Draft ECETOC Report, 2010).
Route to route extrapolation:
Oral->inhalation: 1 (TMQ is an organic solid pastille at room
temperature with a melting point of 48°C (Currenta, 2010) and a very low
vapour pressure <4.8 * 10-6 hPa at 25°C (Monsanto, 1980). Therefore
inhalation exposure to vapour can be excluded. TMQ is a complex reaction
mass (Mw approx. 500 g/mol) with partially undefined composition (UVCB).
TMQ is expected to be mostly insoluble in water (Bayer AG, 1989); for
general considerations see ECETOC Report, 2003; Draft ECETOC Report,
Severity of effects: 1 (liver is the target organ
Intraspecies factor: 3 for worker and 5 for the general population
(ECETOC Report, 2003; Draft ECETOC Report, 2010).
Overall AF for dermal exposure or inhalation:
Worker: 4 x 3=12
General population: 4 x 5 = 20
DNELworker (long-term) dermal: 1 mg/kg
DNELworker (long-term) inhalation (70 kg body weight and 10 m3 air
inhaled per 8 h shift): 7 mg/m3
DNELgeneral population (long-term) dermal: 0.6 mg/kg
DNELgeneral poplulation (long-term) inhalation (60 kg body weight and 20
m3 air inhaled per day): 1.8 mg/m3
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