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EC number: 500-051-3
CAS number: 26780-96-1
TMQ is of low acute toxicity by the oral and the dermal route of exposure.There are no studies available which evaluate acute inhalation toxicity.
In an early study with limited documentation groups of 5 male and 5
female albino rats were dosed with TMQ in an acute oral toxicity
experiment. Animals were dosed with 2160 to 4470 mg/kg and observed for
14 days. Clinical signs as sluggishness was recorded to start 48 h after
dosing; death occurred during the second to fourth day after treatment.
The calculated LD50 was 3190 mg/kg (95% CL 2730 -3720 mg/kg; de Groot,
1976). Additional acute oral studies cited briefly in the database
support the conclusion that TMQ is of low acute oral toxicity with LD50
values above 2000 mg/kg.
In an early dermal study with limited documentation one rabbit was dosed
with 5010 mg/kg bw and two rabbits were dosed with 7940 mg/kg . Animals
were observed for 14 days. Clinical signs were noted for all animals and
gross autopsy of the survivors indicated hemorrhagic areas of the lung,
discoloration of liver, spleen and kidney and inflammation of the
gastrointestinal tract. The rabbit in the low dose group survived and
one out of two rabbits in the high dose group died after 4 days. No
precise LD50 value can be calculated but a cut-off LD50 can be estimated
to be > 5010 mg/kg bw (D. Birch 1976).
Based on the available information no classification is required
according to the EU classification criteria 67/548/EWG and regulation
no. 1272/2008 (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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