Registration Dossier
Registration Dossier
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EC number: 500-051-3 | CAS number: 26780-96-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation; endpoint record transferred from IUCLID 4
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Kel'man, G.Ya., Gig. Trud. Prof. Zabol. 9(8), 32-36 (1965)
- Title:
- No information
- Author:
- Kel'man, G.Ya., Soviet Rubber Technol. 24, 40-41 (1965)
Materials and methods
Test material
- Reference substance name:
- 1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
- EC Number:
- 500-051-3
- EC Name:
- 1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
- Cas Number:
- 26780-96-1
- Molecular formula:
- (C12H15N)x
- IUPAC Name:
- 2,2,4-trimethyl-1,2-dihydroquinoline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 20 w
- Frequency of treatment:
- 4 h/d, daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2.5, 12.5 mg/l
Basis:
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: 30 d
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
low dose: slight decrease in body weight gain, diminution of
the antitoxic function of the liver, recovery within 30
days; high dose: decrease in body weight gain, depression of
the antitoxic function of the liver, a lowering of
albumens and an increase of gamma-globulin concentrations,
reduction in the intensity of the gas exchange, recovery
within 30 days
Applicant's summary and conclusion
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