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EC number: 500-204-4
CAS number: 68334-05-4
Paternal toxicity was exhibited at 20000 ppm as a slight decrease in
weight gain and an increase in piloerection. There were no obvious
maternal effects at this level.
There were no obvious parental effects at 200 or 2000 ppm, nor were
there any effects of treatment on the reproductive parameters at any
dose level applied. The testes and epididymides weights were essentially
similar in all groups.
The mean number of implants per pregnancy was higher in all the treated
groups compared to controls. However, historical data shows that the
findings in the treated groups were within background ranges for animals
of this age and strain. Rather, it was considered most likely that the
control value was at the lower end of the background range. There were
no obvious effects of treatment on litter size, litter survival, or pup
weights at any dose level and no abnormalities noted among pups.
Under the conditions of this study, the parental NOAEL was considered to
be 2000 ppm (approximately 175 mg/kg/day) and for reproductive
parameters the NOAEL was considered to be 20,000 ppm (approximately 1738
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