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EC number: 500-204-4
CAS number: 68334-05-4
skin: rabbit, not irritating eye: rabbit, not irritating
A skin irritation study according to the OECD guideline 404 was
performed with 3 New Zealand White rabbits (Stitzinger, 2010). The
animals were treated with 0.5 mL of the undiluted test substance for 4
hours under semi-occlusive conditions. The skin reactions were assessed
at approximately 1, 24, 48 and 72 hours after the removal of the
dressings and test substance. Four hours exposure resulted in very
slight erythema and very slight oedema in the treated skin areas of the
three rabbits. The skin irritation resolved within 48 hours after
exposure in all animals. There was no evidence of a corrosive effect on
the skin. Sticky remnants of the test substance were present on the skin
immediately after removal of the test substance and dry remnants of the
test substance were present on Day 1 at the 1 hour observation time
point. No staining of the treated skin by the test substance was
observed. No symptoms of systemic toxicity were observed in the animals
during the test period and no mortality occurred.
An eye irritation study according to the OECD guideline 405 was
performed with 3 New Zealand White rabbits (Stitzinger, 2010). 0.1 mL of
the undiluted test substance was instilled in eyes of the animals and
the eyes of each animal were examined approximately 1, 24, 48 and 72
hours after instillation. Observations revealed irritation of the
conjunctivae, which consisted of redness and discharge. The irritation
completely resolved within 48 hours in all animals. No iridial
irritation or corneal opacity was observed, and treatment of the eyes
with 2% fluorescein 24 hours after test substance instillation revealed
no corneal epithelial damage. There was no evidence of ocular corrosion.
Remnants of the test substance were present on the outside of the
eyelids on Day 1. No staining of (peri) ocular tissues by the test
substance was observed. No symptoms of systemic toxicity were observed
in the animals during the test period and no mortality occurred.
According to DSD (67/548/EEC) or CLP (1272/2008/EC) classification
criteria for irritation/corrosion, fatty acids, C18-unsatd., dimers,
2-ethylhexyl esters have not to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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