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EC number: 500-204-4
CAS number: 68334-05-4
palmitoyl-CoA oxidation, a marker for peroxisome proliferation, was
found elevated in a subchronic study in Fischer 344 rats after gavage
application of 500 mg/kg but not under the conditions of this 90-day
subchronic inhalation study.
A 90-day subchronic inhalation toxicity study was performed on
Wistar rats with 2-ethylhexan-1-ol (CAS No. 104-76-7) in accordance to
OECD guideline 413 (Klimisch, 1998). 10 males and 10 females per group
were exposed to 2-ethylhexanol vapours at concentrations of 15, 40 and
120 ppm (the latter corresponding to the vapour saturation at 20ºC) 6
hours/day on working days for 90 days. The respective controls inhaled
clean air under the same conditions. No substance-related adverse
effects were observed for body weight, body weight gain, mortality,
organ weights, ophthalmoscopy, clinical biochemistry and haematological
parameters including clotting time. There were no findings related to
the treatment with 2-ethylhexanol either at necropsy or at histological
examination. The highest concentration tested under these conditions
(120 ppm) was found to be the NOAEL for male and female rats.
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