Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-466-5
CAS number: 107-13-1
Acrylonitrile produced moderate corneal opacity, moderate iritis and
severe conjunctival irritation in the unwashed treated eye. The treated
eye that was washed after exposure for 20 seconds showed slight
temporary corneal opacity, transient moderate iridic congestion and
moderate conjunctival irritation. The washed eye was normal within 3
days. The unwashed eye showed signs of healing by Day 3, with some
evidence of corneal vascularisation. By Days 14 and 21, mild opacity
remained with traces of vascularisation. The effects were seen in both
rabbits and were not completely reversible in the unwashed eye, while by
washing the eye the effects were considerably lessened, as was the
duration of the effects.
In a guideline-comparable study, 0.1 mL acrylonitrile was instilled into
in the conjunctival sac of the right eye of two rabbits. After 20
seconds the treated eye of one of the rabbits was washed with tap water
for 1 minute, the other rabbit remained unwashed. Corneal
opacity/conjunctive irritation occurred up to 3 days in the washed eye
and up to 21 days in the unwashed treated eye. Acrylonitrile was
therefore found to be an eye irritant under the conditions of this
study. The lack of complete reversibility of corneal effects within the
21-day study period supports the harmonised classification of the
substance for serious eye damage (Cat 1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again