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EC number: 203-466-5
CAS number: 107-13-1
The toxicity of acrylonitrile to fish was determined in the fish early
life stage test, with P. promelas (Fathead minnows using
flow-through conditions. No NOEC could be established for this study as
the growth rate was significantly reduced at the lowest concentration
tested of 0.34 mg/L; a NOEC of 0.17 mg/L is estimated.
Available data are summarised in the EU RAR. The toxicity of
acrylonitrile to fish was determined in the fish early life stage test,
with P. promelas (Fathead minnow) using flow-through conditions.
No NOEC could be established for this study as the growth rate was
significantly reduced at the lowest concentration tested (measured: 0.34
mg/l). The report concluded that this concentration represented the
MATC. The EU RAR concludes that this concentration represents the LOEC
(for risk assessment purposes). The EU RAR calculates a NOEC by applying
an assessment factor of 2 to the LOEC, giving a NOEC of 0.17 mg/l.
A study is also available which investigates the sub-lethal effects of
acrylonitrile on Dicentrarchus labrax (seabass). The LOEC based
on a number of biomarkers was found to be 0.15 mg/L. This has not been
considered for PNEC derivation as the study is not conducted to a known
guideline and is of unknown reliability, and has only been presented
here for informational purposes (Neuparth et al., 2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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