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EC number: 203-466-5
CAS number: 107-13-1
Following inhalation exposure, 15% of the inhaled acrylonitrile was
excreted as thiocyanate - this was identified as the major urinary
metabolite. Levels of excreted 2-hydroxyethylmercapturic acid (HMA) were
higher than levels of 2-cyanoethylmercapturic acid (CMA; 8% of total
urinary radioactivity). As exposure levels increased, the excretion of
thiocyanate became relatively more important as shown by the ratio of
excreted thiocyanate to the sum of CMA and HMA at 4 ppm (0.47), 20 ppm
(0.89) and 100 ppm (2.93).
Intravenous / intraperitoneal dosing
CMA represented 74-78% of total urinary metabolites follwoing iv and ip
dosing; in contrast the urinary levels of excreted thiocyanate were low.
The authors investigated the urinary metabolism of acrylonitrile in the
rat, following exposure by different routes. Adult male Sprague-Dawley
rats were exposed acutely to acrylonitrile using different routes of
administration: inhalation (6 hour exposure), intravevous or
intraperitoneal injection. Urinary metabolites measured at 24 hours
after administration were identified as 2-cyanoethylmercapturic acid
(CMA), 2 -hydroxyethylmercapturic acid (HMA) and thiocyanate. In all
experiments the relationship between excretion of total urinary
metabolites and the degree of exposure was reasonably linear. However,
there was a marked influence of the route of administration on the
pattern excretion. Following i.p. and i.v. injection, CMA was the most
important metabolite while after inhalation it was thiocyanate. The
results of the study indicate an important effect of the dose on the
metabolism and excretion of acrylonitrile.
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