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EC number: 203-466-5
CAS number: 107-13-1
The DNA replicative index, calculated as the amount of ³H-thymidine
incorporated in DNA of acrylonitrile-treated animal/control, was
significantly lower than 1.0 at all time points, thus implying a
significant decrease in lung DNA replication resulting from a single
oral dose of acrylonitrile. As replicative DNA synthesis is blocked by
hydroxyurea, the authors attributed the thymidine incorporation to DNA
Acrylonitrile was administered to Sprague-Dawley rats in a single oral
dose of 46.5 mg/kg bw. Replicative DNA synthesis and UDS in lung DNA was
measured by the ratio of tritiated thymidine incorporated following
hydroxyurea suppression at 0.5, 3, 6, 12, or 72 hours after
administration. The authors reported decreases in replicative DNA
synthesis of more than 50% at 0.5, 6 and 24 hours after acrylonitrile
administration, and an increased rate of DNA repair at 0.5 and 6 hours;
they conclude that acrylonitrile demonstrates genotoxic effects
following a single oral dose. The EU RAR (2004) advises that results of
studies employing these methods must be interpreted with caution, as
there is no validated UDS assay using lung as a target tissue.
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