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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Topical application with occlusion, single dose for 4 hours.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylonitrile
EC Number:
203-466-5
EC Name:
Acrylonitrile
Cas Number:
107-13-1
Molecular formula:
C3H3N
IUPAC Name:
prop-2-enenitrile

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
10 rats.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
topically applied acrylonitrile with occlusion.
Duration of exposure:
4 hours.
Doses:
200mg/kg.
No. of animals per sex per dose:
10 rats total, no further information available.
Control animals:
not specified
Details on study design:
No further information.
Statistics:
None reported.

Results and discussion

Preliminary study:
Not applicable/no information
Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Deaths 1/10 at 200 mg/kg bw
Mortality:
1 mortality occurred.
Clinical signs:
other: Slight oedema seen in 3 rats 24 hours following exposure.
Gross pathology:
No information.
Other findings:
No information.

Any other information on results incl. tables

No further information.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
1 rat died following 4 hours occluded topical application of acrylonitrile (200 mg/kg bw). Slight oedema was observed in 3 of the surviving rats 24 hours following exposure.
Executive summary:

1 rat (out of 10) died following 4 hours occluded topical application of acrylonitrile (200 mg/kg bw). Slight oedema was observed in 3 of the surviving rats 24 hours following exposure.