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EC number: 203-466-5
CAS number: 107-13-1
Although the validity of the prolonged toxicity study in Daphnia
by Tong et al (1996b) can be questioned in respect of reaching
the conclusion that there are three valid long-term NOECs, the NOEC
determined in the study is consistent with those established in the fish
early life study and the algal toxicity study. A PNEC is derived using
an assessment factor of 10. Applying this factor to the NOEC derived
from the fish early life stage toxicity test in Pimephales promelas gives
a PNEC of 17 μg/L.
The results of microbial toxicity tests and biodegradation studies on
acrylonitrile indicate a potential effect on microorganisms in
wastewater treatment plants, at least on start-up. The reported EC50s
range from 1- >1,800 mg/L. Results with acclimated microbial populations
and in simulation tests have indicated no inhibitory effect of
acrylonitrile at levels as high as 200 mg/L, and a conservative estimate
of 50 mg/L for a NOEC in such populations has been assumed (EU RAR
2004). Application of a factor of 10 to this NOEC derives a PNEC of 5
mg/L for microorganisms in acclimated wastewater treatment plants
handling acrylonitrile on a continuous basis. A factor of 10 is
considered justified given the relatively large body of data on
microbial toxicity of acrylonitrile.
No data are available; studies for this endpoint are waived on the basis
of exposure. The PNEC sediment is of 0.0188 mg/kg is derived using the
equilibrium partitioning method (EPM) based on the PNEC water of 0.017
A PNEC for soil of 0.00268 mg/kg (based on PNEC (aquatic) of 17 μg/L)
can be derived using the equilibrium partition approach.
Acrylonitrile is listed in Annex VI of the CLP Regulation (EC)
1272/2008 with classification as H411, Aquatic Chronic Category 2. No
new data are available, therefore no change to this classification is
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