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EC number: 310-290-3
CAS number: 161907-80-8
2. Maternal findings
Positive control1000 mg/kg EGDE
25 mg/kg brake fluid
Duration of pregnancy- 21 days- 22 days- 23 days
Mean duration (days)
Mean Body weight (g)- day 1- day 7- day 21
Mean Food intake(g/animal/day)- GD 1-7- GD 7-17- GD17 – LD1- LD1 – LD5
animals littered, killed day 25 of gestation
3. Foetal findings
Mean implantation sites
Mean No. of life pups- LD 1- LD 5
Mean birth index
Mean live birth index
Mean viability index
Group mean litter weight (g)- LD 1- LD 5
gestation day LD:
Brake Fluid DOT 4 is considered to have a similar toxicological profile as B-TTEGME. Brake fluid containing 38% B-TTEGME (of wich 17% B-TEGME) was administered to groups of 10 mated female CD-1 rats from gestation days 7 -17 at doses of 0, 25, 150, or 1000 mg brake fluid/kg bw/day, corresponding with 0, 9.5, 57 and 380 mg B-TTEGME/kg bw/day. Dams were allowed to litter and the pups observed and weighed on days 1 and 5 post-partum, at which point the study was terminated. No treatment related effects on birth, live birth, or viability indices were found. No treatment-related clinical effects were seen on dams or pups, and there were no gross abnormalities seen in the pups. The NOAEL for this study was at least 1000 mg brake fluid /kg bw/day for systemic, reproductive, and developmental toxicity, corresponding with 380 mg B-TTEGME/kg bw/day.
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