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EC number: 310-290-3
CAS number: 161907-80-8
log Kow of main components/hydrolysis products: < 1 at 20°C
For the evaluation of the log Pow
experimental data and QSAR analysis are available:
In an experimental study with a B-TTEGME
containing Brake Fluid it was demonstrated that B-TT EGME has a very low
potential to accumulate in organic matrices. In this GLP
with Brake Fluid DOT 4, containing 35% B-TTEGME, the log Pow of the constituents
of the brake fluid were determined. none of the major components of the
Brake fluid had a log Pow of higher than 0.5.
finding was supported by QSAR analysis. Since B-TTEGME is a mixture,
it is not possible to perform one QSAR analysis for B-TTEGME alone.
Instead, representative constituents of B-TTEGME, i.e., B-TEGME,
B-TetraEGME and B-PentaEGME were analysed.
is mixture of different borated glycol esters. The length of the glycol
ester moiety ranges from 3 to 5 glycols per glycol ester moiety. About
50 % of B-TTEGME have a chain length of 3 glycols per glycol ester
moiety. The molecule with the chain length of 3 glycol esters is
registered under the name B-TEGME (cas# 30989 -05 -0). The
molecule with the chain length of 4 glycol esters (B-TetraEGME) has the
cas 57057 -98 -4. The molecule with a chain length of 5 has the
cas # 75672 -72 -9. B-TEGME and B-PentaEGME represents the extremes for
the glycol ester chain length of B-TTEGME. Hence, they can be considered
to be representative for the risk assessment. The QSARs for the log Pow
were performed using the software EPIWIN40 with the kowwin module
(version 1.67). This QSAR software is recommended in the "Guidance on
information requirements and chemical safety assessment Chapter R.7a:
Endpoint specific guidance", Section R.7.1.8 page 103. The kowwin module
calculates the log Pow based on the fragment addition method.
Results of the QSAR analysis:
The Epiwin kowwin (version 1.67) calculation
resulted in a log Pow of -4.37 for B-TEGME, -5.19 for B-TetraEGME and
-6.01 for B-PentaEGME.
Impact of the glycol ester moieties:
QSARs were performed for glycol esters with
chain lengths of 3 (B-TEGME), 4 (B-TetraEGME) and 5 (B-PentaEGME),
resulting in log Pows of -4.37, -5.19, and -6.01, respectively. Based on
this trend of decreasing log Pow with increasing chain length, the log
Pow value obtained for B-TEGME must be considered to be a worst case for
B-TTEGME (B-TEGME is the smallest molecule in B-TTEGME). The log Pow of
B-TEGME of -4.37 indicates a low risk for bioaccumulation.
Summary and Conclusion for B-TTEGME:
Based on the experimental finding and the
QSAR analysis, the log Pow of B-TTEGME is clearly below 1. The risk
assessment will be made with a log Pow of 1 which must be considered as
worst case scenario of a B-TTEGME.
Both the experimental study and the QSAR
indicate that a log Pow of 1 represents a worst case scenario. This
value will be used for the risk assessment of B-TTEGME.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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