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EC number: 310-290-3 | CAS number: 161907-80-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1990-02-20 to 1990-03-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is well documented and performed according to generally valid and/or internationally accepted testing guidelines. The test material contained a high percentage of the test substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Brake Fluid DOT 4 Super containing B-TTEGME
- IUPAC Name:
- Brake Fluid DOT 4 Super containing B-TTEGME
- Details on test material:
- - Name of test material (as cited in study report): Brake fluid DOT 4 Super
- Physical state: Liquid
- Analytical purity: 76% B-TTEGME
- Impurities (identity and concentrations): Confidential details on test material
- Composition of test material, percentage of components: Confidential details on test material
- Purity test date: Not provided
- Lot/batch No.: KSLA Ref. 7842/89 (0.0039); Toxicology Ref. No. ST90/023
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K. Ltd.
- Age at study initiation: 8-9 weeks
- Weight at study initiation: Cfr. Table 2
- Fasting period before study: Overnight
- Housing: stainless steel cages, groups of max. 3 of same sex
- Diet (ad libitum): pelleted diet (LAD 1, Special Diets Service Ltd.)
- Water (ad libitum): public supply water
- Acclimation period: min. 4 days
- On the day before dosing, the dorsal fur was removed using electric clippers.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23
- Humidity (%): 30-70
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1991-12-09 To: 1991-12-24
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6x8 cm
- % coverage: 100
- Type of wrap if used: waterproof adhesive type
REMOVAL OF TEST SUBSTANCE
- Washing (if done): warm ditlute detergent solution
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.89 ml/kg body weight
- Concentration (if solution): undiluted
- Constant volume or concentration used: no - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females/sex
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 5 observations on the day of dosing and twice daily thereafter; body weights on days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: not applicable
- Euthanasia by i.p. injection of sodium pentobarbitone. - Statistics:
- Not applicable
Results and discussion
- Preliminary study:
- A preliminary test utilising one male and one female rat treated at 2000 mg/kg indicated that the acute median lethal dermal dose (LD50) was greater than 2000 mg/kg.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Brake fluid DOT 4 Super
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 520 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: B-TTEGME
- Mortality:
- No mortality.
- Clinical signs:
- other: No clinical signs. There were no signs of systemic reaction to treatment. Sites of application showed no irritation or other dermal changes.
- Gross pathology:
- No macroscopic changes at the time of necropsy. Sites of appliation of the test material showed no irritation or other dermal change.
- Other findings:
- Not applicable.
Any other information on results incl. tables
Table 2. Body weights in males and females (gram)
Male No. |
Body weight |
Body weight change |
|
Female No. |
Body weight |
Body weight change |
||
Day 1 |
Day 8 |
Day 15 |
|
Day 1 |
Day 8 |
Day 15 |
||
858 M |
206 |
+1 |
+15 |
|
858 F |
142 |
+6 |
+16 |
859 M |
213 |
+8 |
+19 |
|
859 F |
150 |
+4 |
+16 |
860 M |
221 |
+3 |
+22 |
|
860 F |
141 |
+5 |
+18 |
861 M |
219 |
+3 |
+16 |
|
861 F |
151 |
+6 |
+17 |
862 M |
208 |
+7 |
+20 |
|
862 F |
153 |
+6 |
+16 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The acute dermal LD50 of Brake fluid Dot 4 in rats was greater than 2000 mg/kg body weight, corresponding with 1520 mg B-TTEGME/kg.
- Executive summary:
Brake Fluid DOT4 Super is considered to have a similar toxicological profile as B-TTEGME. The acute dermal LD50 of Brake fluid Dot 4 Super (containing 76 % B-TTEGME) in fasted rats was greater than 2000 mg/kg body weight, corresponding to more than 1520 mg B-TTEGME/kg body weight. The test material was applied undiluted to the clipped dorsum at 1.88 ml/kg body weight, corresponding to 2000 mg/kg body weigth, and kept in place under occlusive dressing for 24 hours. All five male and five female rats survived without clinical signs. All rats had gained weight relative to their day 1 body weight by the end of the 14 day observation period. No macroscopic changes were apparent during necropsy of the treated rats on Day 15.
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