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EC number: 310-290-3
CAS number: 161907-80-8
Table 2. Clinical observations in males
Animal No. & sex
Time of first detection
Time of recovery
Periorbital zone – encrustation
Table 3. Clinical observations in females
Table 4. Body weights in males and females (gram)
Body weight change
Fluid DOT4 Super is considered to have a similar toxicological profile
The acute oral LD50 of Brake fluid Dot 4 Super in
fasted rats was greater than 5000 mg/kg body weight, corresponding to
greater than 3800 mg B-TEGME/kg body weight. The undiluted test material
was administered by oral gavage at 4.70 mL/kg body weight. Five male and
five female rats were dosed at 5000 mg/kg and all survived. The sole
common sign of reaction to treatmentwas a hunched posture apparent from
within 1 hour of dosing. Other isolated clinical signs were
lachrymation, abasia, lethargy, unkempt appearance and encrustation of
the periorbital zone. Recovery, as judged by external appearance and
behavior, was complete by day 3. All rats had gained weight relative to
their day 1 body weight by the end of the 14 day observation period. No
macroscopic changes were apparent during necropsy of the treated rats on
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