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EC number: 310-290-3
CAS number: 161907-80-8
Cfr. Table 1 in attachment
Fluid DOT 4 is considered to have a similar toxicological profile as
B-TTEGME. The clastogenic potential of the
brake fluid containing 38% B-TTEGME was assessed from assays designed to
detect chromosome damage in cultured Chinese Hamster Ovary (CHO) cells.
Cultures were grown in tissue culture flasks and incubated in medium
containing the test compound or relevant controls for either 3 hours in
the presence of S9 mix or for 24 hours in the absence of S9 mix.
Metaphase cells were prepared on glass microscope slides for the
analysis of chromosome aberrations 24 hours following initiation of
compound exposure for the cultures both with and without S9 mix.
The data generated from this study show that brake
fluid and therefore also B-TTEGME did not induce structural chromosome
aberrations in cultured CHO cells both in the presence and in the
absence of S9 mix, under the experimental conditions described.
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