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EC number: 310-290-3
CAS number: 161907-80-8
B-TTEGME applied in brake fluids was well tolerated in rabbits (and guinea-pigs) after dermal and ocular testing for irritation and corrosion. Scoring values were slight and reversible. The test substance is considered to be non-irritating for skin and eye.
skin and eye irritation and corrosion of B-TTEGME were studied by
read-across with data from various test materials, including Brake Fluid
DOT4 Super, Brake Fluid DOT 4 and B-TEGME. Similarity with B-TTEGME was
based on a common functional group, common precursors and/or likelihood
of common breakdown products and common constituents, as also described
in a separated justification document in Section 13.
key study for dermal irritation was
conducted in vivo by semi-occlusive testing of a brake
76% B-TTEGMEof which ca. 45% was
B-TEGME, corresponding with 37% in the tested brake fluid.
Application on rabbit skin
at the dose of 0.5 mL during 4 hours demonstrated that the substance was
not irritating to the skin up to 7 days after application (Shell,1990c).
This study was applied according to OECD 404 guideline and was
considered to be adequate, reliable and relevant.Weight of
applied to the same method by semi-occlusive topical application on
rabbit skin for 4 hours, demonstrated that the substance was not
irritating to the skin up to 7 days after application (Clariant, 1995c).
B-TEGME applied to rabbit skin (for 1, 5, 15' and 20h) and rabbit ear
(for 20h) induced doubtful erythema only after 20h exposure to the skin
and ear. Observations on day 8 after exposure did not reveal any
findings (BASF, 1974b).
brake fluid (e.g.
containing 38% B-TTEGME of which ca.
50% was B-TEGME, corresponding with 17% in the tested brake fluid;
Shell, 1990a) conducted according to OECD 404 also confirmed the absence
of skin irritating potential (Shell, 1975 and 1977).
key study for eye irritation was
conductedin vivoon rabbit eyes by testing a brake
76% B-TTEGMEof which ca. 45% was
B-TEGME, correspond ding with 37% in the tested brake fluid.
Application was done according to guideline OECD 405at the volume of 0.1
mL (Shell, 1990d). Some irritation (conjunctival redness, slight
chemosis and slight ocular discharge) was observed, however with a mean
score of 0.3 resolving within 48-72 hours of treatment.Weight
not reveal eye irritation when applied to the same method undiluted at
0.1 mL in one study (Clariant, 1995b). In an older study with B-TEGME,
slight irritation was observed, however the method was different and the
effect was reversible within 8 days(BASF, 1974c).
slight and reversible conjunctival reaction (mean score of 0.4 only for
conjuctival redness), was also observed in a supporting
abrake fluid containing
38% B-TTEGME,of which ca. 45% was
B-TEGME, corresponding with 17% in the tested brake fluid (Shell,
1992c). Two other supporting studies did not reveal any ocular findings
(Shell, 1975 and 1977). The cornea and iris were never visibly affected
by the test material.
findings were therefore not significant for classification.
B-TTEGME in brake fluids did not result in skin
irritation, therefore no classification is warranted.
B-TTEGME in brake fluids caused some slight and
reversible conjuctival redness and chemosis on the eyes (with a mean
score of 0.3 -0.4), however there was no corneal opacity nor iris
change, therefore classification is not warranted.
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