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EC number: 207-236-5
CAS number: 455-14-1
Only one study (Chrysalis, 1995) with
reliability 1 was available and was selected as key study. The summary
of this study is the following:
a dermal sensitization study (Chrysalis, 1995) with
p-trifluoromethylaniline in absolute ethanol, Hartley guinea pigs
(10/sex in test groups and 5/sex in control group) were tested using the
method of maximization.
2/20 animals presented
positive reaction. It is not sufficient to consider p-TFMA for
sensitization. 30% of positive reaction is necessary to classify a test
item as skin sensitizer.
Burnt appearance of
the skin on a surface less than one quarter of the application area was
noted for 2 males. 1 male and 2 females presented scratches to the
At dose of 1%,
p-trifluoromethylaniline was not considered as dermal sensitizer,
according to the EC classification criteria (67/548/EC directive) and
Based on results of the available study,
p-TFMA could be considered as not sensitizing.
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