Registration Dossier
Registration Dossier
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EC number: 207-236-5 | CAS number: 455-14-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publication in Russian, a short summary was available in english. The study seems to be well described, and 2 species were tested. This data is cited in DOSE, Sax's.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Khalepo
- Year:
- 1 968
- Bibliographic source:
- Toksikol. Nov. Prom. Khim. Veshchestv, 10, p : 131-140
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- no
- Test type:
- other: inhalation study, no more data
Test material
- Reference substance name:
- α,α,α-trifluoro-m-toluidine
- EC Number:
- 202-643-4
- EC Name:
- α,α,α-trifluoro-m-toluidine
- Cas Number:
- 98-16-8
- Molecular formula:
- C7H6F3N
- IUPAC Name:
- 3-(trifluoromethyl)aniline
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 220 +/- 40 g
ENVIRONMENTAL CONDITIONS:
- Temperature (°C): 28°C
No more data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
No more data - Statistics:
- according to Litchfield & Wilcoxon, corrected by Pot
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.44 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (0.40-0.49 mg/L) for rats
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.69 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (0.60-0.79 mg/L) for mice
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP classification: Toxicity Category III
- Executive summary:
In an acute inhalation toxicity study (Khalepo, 1968), groups of rats and mice were exposed by inhalation route to meta-trifluoromethylaniline for 4 hours. Animals were observed for 2 weeks. LC50= 0.44 mg/L for rats and 0.69 mg/L for mice.
Meta-trifluoromethylaniline is classified as toxic T R23 by inhalation route, according to the EU classification criteria (67/548/EC directive).
It is classified acute category 3 (H331), according to CLP criteria.
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