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EC number: 207-236-5
CAS number: 455-14-1
Eye irritation score table:
n. = not reversible
In a primary eye
irritation study (Hazleton,
1985), 0.1 ml of undiluted paratrifluoromethylaniline (>98.5) was
instilled into the conjunctival sac of one eye of 6 New Zealand White
rabbits. Animals then were observed for 3 days. Irritation was scored by
the method according to criteria of directive EC 67/548.
After 72 hours, the overall irritation was Chemosis:2.34;Conjonctiva:
1.5; Iris: 1; Cornea: 2, were not fully reversible within 72 h.
Based on this study, p-trifluoromethylaniline (>=98.5%) is considered
severely irritating to the eye and was classified XI R41 according to
the Annex VI of the directive 67/548/EC, and Eye damage Cat. 1 H318
according to the CLP criteria.
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