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EC number: 207-236-5 | CAS number: 455-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Available studies gave the following results:
Oral LD50 (rat): 128 mg/kg bw
Dermal LD50 (rat): >= 2002 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 128 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 002 mg/kg bw
Additional information
Acute oral toxicity:
Only one study was available (Hazleton, 1985). It was with reliability 1 and was selected as key study. The summary of this study was the following:
In
an acute oral toxicity study (Hazleton, 1985), groups of fasted, 6-7
weeks old Sprague-Dawley rats males and females (5/sex) were given a
single oral dose of p-trifluoromethylaniline (purity >=98.5%) in arachid
oil at doses 0, 100, 126, 156, 182, 195 mg/kg bw and observed for 14
days.
Oral LD50 Combined = 128 mg/kg bw (111-149 mg/kg).
Based on these results, p-trifluoromethylaniline is considered as toxic
by oral route and classified T R25 according to the 67/548/EC directive.
It is classified acute tox. Category 3 (H301), based on CLP criteria.
Acute dermal toxicity:
Only one study was available (Hazleton, 1986). It was with reliability 1 and was selected as key study. The summary of this study was the following:
In
an acute dermal toxicity study (Hazleton,
1986), groups of young adult Sprague-Dawley rats males and females
(5/sex) were dermally exposed to p-trifluoromethylaniline (>=98.5%) for
24 hours to lateral-dorsal at doses of 0, 2002 mg/kg mg/kg bw. Animals
then were observed for 14 days.
Dermal LD50 Males = >2002 mg/kg bw
Females = >2002 mg/kg bw
Combined = >2002 mg/kg bw
Based on these results, p-trifluoromethylaniline is not classified by
dermal route.
Acute inhalation study:
No data were available for p-TFMA. A read accross with m-trifluoromethylaniline was done.
One russian publication was available and was cited in Sax's Handbook and in HSDB database. The study was not well detailed because only a summary in english was given.
In this publication, the LC50 reported were0.44and 0.69 mg/L in rats and mice respectively.
One unpublished report (Hoechst GLP study, 1987) reported a LC50 range of 5.67 -6.29 mg/l air without more details.
Taking into account these values, p-trifluoromethylaniline could be classified as toxic T R23 by inhalation route, according to the EU classification criteria (67/548/EC directive) and acute category 3 (H331), according to CLP criteria because m-TFMA and p-TFMA are position isomers.
Justification for classification or non-classification
Based on available studies, p-TFMA could be considered as toxic by oral route and not harmful by dermal route, according to the EC classification criteria.
By analogy with m-TFMA, p-TFMA could be considered as toxic by inhalation route.
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