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EC number: 207-236-5
CAS number: 455-14-1
Irritant/corrosive response data for each
animal at each observation time up to removal of each animal from the
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Average 24h, 48h, 72h
n for 2 animals
Average time (unit) for reversion
*: reaction out of
** Reversibility: n. =
a primary dermal irritation study (Hazleton, 1985), 6 rabbits were
dermally exposed to p-trifluoromethylaniline (>=98.5%) for 4 hours to
6.25 cm2 of dorsal/flank skin. Test site was covered with a
semi-occlusive patch for 4 hours. Animals then were observed 1, 24, 48
an 72 hours after removal the substance.
Irritation was scored following the erythema and oedema scale of EU
mean value of erythema score was 0.44 without complete reversibility
after 72h. No oedema effects were observed.
In this study, p-trifluoromethylaniline (>=98.5%) is slightly irritating
but not a dermal irritant to the skin based on EU classification
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