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EC number: 207-236-5
CAS number: 455-14-1
Available studies gave the following results:p-TFMA is slightly irritating to the skin but not classified for this endpoint, and highly irritating to the eyes.
Only one study was available (Hazleton,
1985), with reliability 2 and was selected as key study. Its summary was
a primary dermal irritation study (Hazleton, 1985), 6 rabbits were
dermally exposed to p-trifluoromethylaniline (>=98.5%) for 4 hours to
6.25 cm2 of dorsal/flank skin. Test site was covered with a
semi-occlusive patch for 4 hours. Animals then were observed 1, 24, 48
an 72 hours after removal the substance.
Irritation was scored following the erythema and oedema scale of EU
mean value of erythema score was 0.44 without complete reversibility
after 72h. No oedema effects were observed.
In this study, p-trifluoromethylaniline (>=98.5%) is slightly irritating
but not a dermal irritant to the skin based on EU classification criteria
(67/548/EC diective ) and CLP criteria.
a primary eye irritation study (Hazleton, 1985), 0.1 ml of undiluted
paratrifluoromethylaniline (>98.5) was instilled into the conjunctival
sac of one eye of 6 New Zealand White rabbits. Animals then were
observed for 3 days. Irritation
was scored by the method according
to criteria of directive EC 67/548.
After 72 hours, the overall irritation was Chemosis: 2.34; Conjonctiva:
1.5; Iris: 1; Cornea: 2, were not fully reversible within 72 h.
Based on this study, p-trifluoromethylaniline (>=98.5%) is considered
severely irritating to the eye and was classified XI R41 according to
the Annex VI of the directive 67/548/EC, and Eye damage Cat. 1 H318
according to the CLP criteria.
Based on results of these available studies,
p-TFMA could be considered as not irritating to the skin and highly
irritating to the eyes, according to the EC classification criteria.
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