Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-236-5
CAS number: 455-14-1
case of severe methemoglobinemia after occupational exposure to
p-trifluoromethylaniline was reported. Poisoning resulted from
inhalation but especially gross contamination of the hands of the
worker, while operating without any individual safety device in the tank
of a truck, previously emptied and cleaned out. The severity of
methemoglobinemia required admission in a critical care unit and
administration of methylene blue.
pathophysiology and therapy of methemoglobinemia were discussed. The
circumstances of the intoxication were explicated.
worker with only dust mask and cloth gloves had to intervene in the tank
of a truck. Presence of solvent odour and feeling of intoxication had to
conduct him to go out to fresh air. After 2 hours and half of working
(at 17h30), he complained about intense headaches, nausea, dizziness and
difficulties in breathing, but no sensation of irritation on skin or
a slight feeling of faintness, he had an accident without gravity.
of persistence of symptoms, and observation of blue color on lips, gums
and fingers, he was carried to hospital.
was not altered. Marked cyanosis persists on lips, hands, ears and feet
in contrast with globally satisfactorily hemodynamic.
the other hand, pulse oxymometry showed a decrease of saturation (SpO2)
at 65%. Blood analysis showed methemoglobinemia at 55.9% for a total
hemoglobin at 153 g/l and a carboxyhemoglobin at 0.3%.
began at 22h30
therapy. There was a severe hypoxemia and methemoglobinemia at 57.8%.
a treatment with Blue methylene, Fluimicil perfusion and vitamin C,
functional signs, cyanosis and hypoxia disappeared.
decrease at 10.5%, the next day (at 6h) at 3.6% and at 0.1% at midday,
then around 18 hours after exposition.
tests showed that liver, kidneys or muscles were not affected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again