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Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
100 mg/kg bw/day
Additional information

A Reproduction/Developmental Toxicity screening Test was performed in male and female rats. 25, 50 and 100 mg/kg bw MMP was administered via oral gavage to 10 males per dose for at least 28 days and 10 females per dose for 14 days prior to pairing, through the pairing and gestation periods until the F1 generation reached day 4 post partum. All parental animals survived until scheduled necropsy. At all concentrations, there were no treatment-related effects on precoital time, fertility indices, mean duration of gestation, number of implantations, post-implantation loss, pup survival, litter size, sex ratio or mean pup weight development from birth through to scheduled sacrifice on day 4 post partum. Therefore, the NOAEL for reproduction and developmental toxicity was determined to be 100 mg/kg bw. Based on the available data, no classification is required for the reproduction toxicity endpoint for MMP.


Short description of key information:
High quality reproductive/developmental screening study according to OECD guideline 422 is available.

Effects on developmental toxicity

Description of key information
High quality reproductive/developmental screening study according to OECD guideline 422 is available.
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
100 mg/kg bw/day
Additional information

A Reproduction/Developmental Toxicity screening Test was performed in male and female rats. 25, 50 and 100 mg/kg bw MMP was administered via oral gavage to 10 males per dose for at least 28 days and 10 females per dose for 14 days prior to pairing, through the pairing and gestation periods until the F1 generation reached day 4 post partum. All parental animals survived until scheduled necropsy. At all concentrations, there were no treatment-related effects on precoital time, fertility indices, mean duration of gestation, number of implantations, post-implantation loss, pup survival, litter size, sex ratio or mean pup weight development from birth through to scheduled sacrifice on day 4 post partum. Therefore, the NOAEL for reproduction and developmental toxicity was determined to be 100 mg/kg bw. Based on the available data, no classification is required for the reproduction toxicity endpoint for MMP.

Justification for classification or non-classification

Reproductive toxicity - Reason for no classification: conclusive but not sufficient for classification

Effects on lactation - Reason for no classification: data lacking

Additional information

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