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EC number: 220-912-4
CAS number: 2935-90-2
A Reproduction/Developmental Toxicity screening Test was performed in
male and female rats. 25, 50 and 100 mg/kg bw MMP was administered via
oral gavage to 10 males per dose for at least 28 days and 10 females per
dose for 14 days prior to pairing, through the pairing and gestation
periods until the F1 generation reached day 4 post partum. All parental
animals survived until scheduled necropsy. At all concentrations, there
were no treatment-related effects on precoital time, fertility indices,
mean duration of gestation, number of implantations, post-implantation
loss, pup survival, litter size, sex ratio or mean pup weight
development from birth through to scheduled sacrifice on day 4 post
partum. Therefore, the NOAEL for reproduction and developmental toxicity
was determined to be 100 mg/kg bw. Based on the available data, no
classification is required for the reproduction toxicity endpoint for
High quality reproductive/developmental screening study according to OECD guideline 422 is available.
Reproductive toxicity - Reason for no classification: conclusive but not
sufficient for classification
Effects on lactation - Reason for no classification: data lacking
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