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EC number: 220-912-4
CAS number: 2935-90-2
In a bacterial reverse mutation assay with multiple strains of
Salmonella typhimurium (similar to OECD TG 471), MMP was negative both
with and without metabolic activation. In a mammalian cell gene mutation
assay with L5178Y mouse lymphoma cells, exposure to MMP (similar to OECD
TG 476) in the presence and absence of metabolic activation did not
induce dose-dependent increases in mutation frequency. In an in vitro
chromosome aberration test (OECD 473) with and without metabolic
activation, MMP did not induce chromosomal aberrations in Chinese
hamster V79 cells. MMP induced sister chromatid exchanges (SCE; similar
to OECD TG 479) in Chinese hamster ovary cells in the presence and
absence of metabolic activation. Although SCE were induced in the
presence and absence of metabolic activation by MMP in vitro, based on
the consistent lack of genotoxicity in in vitro bacterial and mammalian
tests systems MMP is considered to be non genotoxic in vitro and
therefore, does not warrant classification.
Genetic toxicity - Reason for no classification: conclusive but not
sufficient for classification
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