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EC number: 220-912-4
CAS number: 2935-90-2
An appropriate oral repeated dose toxicity study is available in methods comparable to OECD guideline 407.
A repeat dose study was performed in male rats as a part of a
Reproduction/Developmental Toxicity Screening test. 10 males per dose
were treated via oral gavage with 25, 50 and 100 mg/kg bw MMP for 28
days. 50 kg bw was determined to be the NOAEL, based on four males in
the high dose group displaying a minimal to slight hyperplasia of the
forestomach squamous epithelium partly associated with a minimal to
slight hyperkeratosis and minimal inflammatory cell infiltrations.
Although these effects were considered to be treatment related,
proliferative lesions of the rodent non-glandular stomach region are
relatively common in gavage and feeding studies and are not relevant to
humans because of lack of a forestomach. Liver weights relative to body
weight and brain weight were dose-dependently increased in the mid and
high dose groups, but in the absence of a histological correlation the
increases were considered toxicologically irrelevant. However, the study
was conducted for 28-days (instead of a 90-days) and failed to report on
possible adverse histological effects at dose levels above 100 mg/kg bw.
A classification for the repeat dose toxicity endpoint cannot be made
due to insufficient data.
Specific target organ toxicity repeated - Reason for no classification:
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