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EC number: 220-912-4
CAS number: 2935-90-2
Methyl 3-mercaptoproprionate was topically applied to the dorsal surface
of the ear of CBA/Ca female mice in a local lymph node assay (LLNA). A
preliminary screening test was conducted in which no clinical signs of
toxicity were noted at a concentration of 25% v/v in acetone/olive oil
(4:1). Thus, mice (five/group) were treated with 50 uL (25 uL per ear)
with concentrations of 5, 10 or 25% methyl 3 -mercaptoproprionate v/v in
acetone/olive oil (4:1). An additional group of mice was treated with
acetone/olive oil (4:1). The Stimulation Index (SI) expressed as the
mean radioactive incorporation for each treatment group divided by the
mean radioactive incorporation of the vehicle control was less than
three for all of the treatment groups. Thus, methyl 3
-mercaptoproprionate was considered to be a non-sensitiser under the
conditions of the test.
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