Reaction mass of butyl diphenyl phosphate and dibutyl phenyl phosphate and tributyl phosphate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1979

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The study protocol is poorly documented.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Primary skin irritation test. Erythema and edema were scored on intact and abraded skin of New Zealand rabbits after 24 and 72 h.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Acryloid HF-422 (DBPP - polymer)

IUPAC Name:

Acryloid HF-422 (DBPP - polymer)

Constituent 2

Reference substance name:

Dibutyl phenyl phosphate

EC Number:

219-772-7

EC Name:

Dibutyl phenyl phosphate

Cas Number:

2528-36-1

Molecular formula:

C14H23O4P

IUPAC Name:

dibutyl phenyl phosphate

Details on test material:

Acryloid HF-422 (70.8% dibutylphenylphosphate and 29.2% n-butylmethacrylate polymer)

Test animals

Species:

rabbit

Strain:

other: New Zealand

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

0.5 mL applied

Number of animals:

6 animals: 3 males and 3 females

Details on study design:

SCORING SYSTEM: max. score = 8, erythema + edema

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

24 h

Score:

ca. 1

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

24 h

Score:

ca. 0

Results 3

Irritation parameter:

erythema score

Basis:

mean

Time point:

72 h

Score:

ca. 0

Results 4

Irritation parameter:

erythema score

Basis:

animal #6

Time point:

72 h

Score:

ca. 1

Results 5

Irritation parameter:

edema score

Basis:

mean

Time point:

72 h

Score:

ca. 0

Any other information on results incl. tables

h	24				72
	ERYTHEMA		EDEMA		ERYTHEMA		EDEMA
	intact	abraded	intact	abraded	intact	abraded	intact	abraded
1 male	1	1	0	0	0	0	0	0
2 male	0	1	0	0	0	0	0	0
3 male	0	1	0	0	0	0	0	0
4 female	0	1	0	0	0	0	0	0
5 female	0	1	0	0	0	0	0	0
6 female	1	1	0	0	1	1	0	0

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

Acryloid HF-422 can be classified as "non-irritant" to the skin.