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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study protocol is poorly documented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Primary skin irritation test. Erythema and edema were scored on intact and abraded skin of New Zealand rabbits after 24 and 72 h.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Acryloid HF-422 (70.8% dibutylphenylphosphate and 29.2% n-butylmethacrylate polymer)

Test animals

Species:
rabbit
Strain:
other: New Zealand

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 mL applied
Number of animals:
6 animals: 3 males and 3 females
Details on study design:
SCORING SYSTEM: max. score = 8, erythema + edema

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
ca. 1
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
ca. 0
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Score:
ca. 0
Irritation parameter:
erythema score
Basis:
animal #6
Time point:
72 h
Score:
ca. 1
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Score:
ca. 0

Any other information on results incl. tables

h

24

72

 

ERYTHEMA

EDEMA

ERYTHEMA

EDEMA

 

intact

abraded

intact

abraded

intact

abraded

intact

abraded

1 male

1

1

0

0

0

0

0

0

2 male

0

1

0

0

0

0

0

0

3 male

0

1

0

0

0

0

0

0

4 female

0

1

0

0

0

0

0

0

5 female

0

1

0

0

0

0

0

0

6 female

1

1

0

0

1

1

0

0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Acryloid HF-422 can be classified as "non-irritant" to the skin.