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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study protocol is very poorly documented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute eye irritation test. Cornea, iris and conjunctivae of New Zealand rabbits were scored after 24, 48 and 72 h.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Acryloid HF-422 (70.8% dibutylphenylphosphate + 29.2% n-butylmethacrylate polymer)

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
dose: 0.1 mL
Number of animals or in vitro replicates:
6 animals: 3 males and 3 females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24 h
Score:
ca. 1.67
Max. score:
10
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
48 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
72 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
iris score
Basis:
mean
Time point:
24 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
iris score
Basis:
mean
Time point:
48 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
iris score
Basis:
mean
Time point:
72 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24 h
Score:
ca. 1
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
48 h
Score:
ca. 0.67
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
72 h
Score:
ca. 0.33
Max. score:
2

Any other information on results incl. tables

 

24

48

72

 

cornea

iris

conj.

cornea

iris

conj.

cornea

iris

conj.

1 male

0

0

2

0

0

0

0

0

0

2 male

0

0

0

0

0

0

0

0

0

3 male

10

5

2

5

5

2

5

5

2

4 female

0

0

0

0

0

0

0

0

0

5 female

0

0

2

0

0

2

0

0

0

6 female

0

0

0

0

0

0

0

0

0

Applicant's summary and conclusion

Conclusions:
Acryloid HF-422 can be classified as a slight irritant to the eye.