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EC number: 907-672-2 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study protocol is very poorly documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute eye irritation test. Cornea, iris and conjunctivae of New Zealand rabbits were scored after 24, 48 and 72 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- Acryloid HF-422 (DBPP - polymer)
- IUPAC Name:
- Acryloid HF-422 (DBPP - polymer)
- Reference substance name:
- Dibutyl phenyl phosphate
- EC Number:
- 219-772-7
- EC Name:
- Dibutyl phenyl phosphate
- Cas Number:
- 2528-36-1
- Molecular formula:
- C14H23O4P
- IUPAC Name:
- dibutyl phenyl phosphate
- Details on test material:
- Acryloid HF-422 (70.8% dibutylphenylphosphate + 29.2% n-butylmethacrylate polymer)
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- dose: 0.1 mL
- Number of animals or in vitro replicates:
- 6 animals: 3 males and 3 females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1.67
- Max. score:
- 10
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 0.83
- Max. score:
- 5
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0.83
- Max. score:
- 5
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0.83
- Max. score:
- 5
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 0.83
- Max. score:
- 5
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0.83
- Max. score:
- 5
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 0.67
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0.33
- Max. score:
- 2
Any other information on results incl. tables
|
24 |
48 |
72 |
||||||
|
cornea |
iris |
conj. |
cornea |
iris |
conj. |
cornea |
iris |
conj. |
1 male |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
2 male |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 male |
10 |
5 |
2 |
5 |
5 |
2 |
5 |
5 |
2 |
4 female |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5 female |
0 |
0 |
2 |
0 |
0 |
2 |
0 |
0 |
0 |
6 female |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Conclusions:
- Acryloid HF-422 can be classified as a slight irritant to the eye.
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