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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study protocol is very poorly documented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute eye irritation test. Cornea, iris and conjunctivae of New Zealand rabbits were scored after 24, 48 and 72 h.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Acryloid HF-422 (DBPP - polymer)
IUPAC Name:
Acryloid HF-422 (DBPP - polymer)
Constituent 2
Chemical structure
Reference substance name:
Dibutyl phenyl phosphate
EC Number:
219-772-7
EC Name:
Dibutyl phenyl phosphate
Cas Number:
2528-36-1
Molecular formula:
C14H23O4P
IUPAC Name:
dibutyl phenyl phosphate
Details on test material:
Acryloid HF-422 (70.8% dibutylphenylphosphate + 29.2% n-butylmethacrylate polymer)

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
dose: 0.1 mL
Number of animals or in vitro replicates:
6 animals: 3 males and 3 females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24 h
Score:
ca. 1.67
Max. score:
10
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
48 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
72 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
iris score
Basis:
mean
Time point:
24 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
iris score
Basis:
mean
Time point:
48 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
iris score
Basis:
mean
Time point:
72 h
Score:
ca. 0.83
Max. score:
5
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24 h
Score:
ca. 1
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
48 h
Score:
ca. 0.67
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
72 h
Score:
ca. 0.33
Max. score:
2

Any other information on results incl. tables

 

24

48

72

 

cornea

iris

conj.

cornea

iris

conj.

cornea

iris

conj.

1 male

0

0

2

0

0

0

0

0

0

2 male

0

0

0

0

0

0

0

0

0

3 male

10

5

2

5

5

2

5

5

2

4 female

0

0

0

0

0

0

0

0

0

5 female

0

0

2

0

0

2

0

0

0

6 female

0

0

0

0

0

0

0

0

0

Applicant's summary and conclusion

Conclusions:
Acryloid HF-422 can be classified as a slight irritant to the eye.