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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study protocol is poorly documented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute oral toxicity test. A single oral dose was administered to rats. Animals were observed until 14 days after administration of the test substance. Mortalities, body weights and clinical observations were recorded.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Acryloid HF-422 (70.8% dibutylphenylphosphate and 29.2% n-butylmethacrylate polymer)

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses:
500, 1500, 2500, 3500, 5000 mg/kg
No. of animals per sex per dose:
5 males and 5 females
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 307 mg/kg bw
95% CL:
3 568 - 6 423

Any other information on results incl. tables

One animal at the 2500 mg/kg dose and one at the 5000 mg/kg dose exhibited alopecia. One animal at the 2500 mg/kg dose, two at the 2500 mg/kg dose, two at the 3500 mg/kg dose, and 8 at the 5000 mg/kg dose were hypoactive. Bloody appearing urine was seen in one animal at the 3500 mg/kg dose and in 2 at the 5000 mg/kg dose. One animal at the 3500 mg/kg dose and one at the 5000 mg/kg dose had ptosis. Ataxia was seen in one animal at the 3500 mg/kg dose and in 5 animals at the 5000 mg/kg dose. Excessive lacrimation was observed in one animal at the 3500 mg/kg dose and in 4 animals at the 5000 mg/kg dose.

Gross necropsy: 20 animals were necropsied at terminal sacrifice. One had very pale lungs. One had very pale colored kidneys. One had unilateral hydronephrosis and white sediment in the same kidney. The remaining 17 animals were not remarkable.

Dose

Body weight (Gm)

Mortalities / dosed

mg/kg

Day 0 M/F

Day 7 M/F

Day 14 M/F

Male

Female

Combined

500

176/173

251/213

300/228

0/5

0/5

0/10

1500

171/171

244/218

293/227

0/5

0/5

0/10

2500

178/178

246/222

297/242

0/5

1/5

1/10

3500

178/168

245/203

307/221

0/5

2/5

2/10

5000

172/171

215/ -

281/ -

2/5

5/5

7/10

Applicant's summary and conclusion