Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study protocol is poorly documented.
Justification for type of information:
This information is in the dossier in support of the RA of the key study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Dermal toxicity test with rabbits. Survival and clinical observations were recorded. A gross pathology was conducted.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Acryloid HF-422 (DBPP - polymer)
IUPAC Name:
Acryloid HF-422 (DBPP - polymer)
Constituent 2
Chemical structure
Reference substance name:
Dibutyl phenyl phosphate
EC Number:
219-772-7
EC Name:
Dibutyl phenyl phosphate
Cas Number:
2528-36-1
Molecular formula:
C14H23O4P
IUPAC Name:
dibutyl phenyl phosphate
Details on test material:
Acryloid HF-422 (70.8% dibutylphenylphosphate and 29.2% n-butylmethacrylate polymer)

Test animals

Species:
rabbit
Strain:
other: New Zealand
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Doses:
dosage: 2000 mg/kg bw
No. of animals per sex per dose:
10 animals: 5 males and 5 females
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
Mortality:
male: 0/5
female: 0/5
Clinical signs:
Six animals had dry and crusty skin in the treatment area. The remaining animals appeared normal.
Gross pathology:
Three animals had necrotic spots on their livers. One animal had white sediment in one kidney. Six animals were not remarkable.

Applicant's summary and conclusion