Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In a test with guinea pigs carried out in accordance with OECD Guideline 406, according to Magnusson and Kligman, PFBE did not exhibit a skin sensitising effect.


Migrated from Short description of key information:
In a test with guinea pigs carried out in accordance with OECD Guideline 406, according to Magnusson and Kligman, PFBE did not exhibit a skin sensitising effect.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

During inhalation studies on PFBE by whole body exposure for up to 28 days showed no evidence of respiratory sensitisation.


Migrated from Short description of key information:
During inhalation studies on PFBE by whole body exposure for up to 28 days showed no evidence of respiratory sensitisation.

Justification for classification or non-classification

In a test with guinea pigs carried out in accordance with OECD Guideline 406, according to Magnusson and Kligman, PFBE did not exhibit a skin sensitising effect. Additionally, inhalation studies on PFBE by whole body exposure for up to 28 days showed no evidence of respiratory sensitisation. Therefore, classification for skin and respiratory senstisation is not warranted under EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.