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EC number: 243-053-7 | CAS number: 19430-93-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other:
- Principles of method if other than guideline:
- No guideline available
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,6-nonafluorohexene
- EC Number:
- 243-053-7
- EC Name:
- 3,3,4,4,5,5,6,6,6-nonafluorohexene
- Cas Number:
- 19430-93-4
- Molecular formula:
- C6H3F9
- IUPAC Name:
- 3,3,4,4,5,5,6,6,6-nonafluorohex-1-ene
- Test material form:
- other: liquid
- Details on test material:
- Purity 99.0%
Impurities present:
3,3,3,4,4-pentafluoro-1-butene = 0.87%
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octene = 0.08%
1,1,1,2,2,3,3,4,4-nonafluoro-4-iodobutane = 0.004%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cr1 : CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Young adult Crl : CD rats with average bodyweight of 242g.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test material, which was used as received, was administered by intragastric intubation in single doses to a group of 10 young adult Cr1 : CD ® male rats. A range finding study was first conducted in the range 670 - 25000 mg/kg bw to determine the initial dose level for the LD50 test. There were no deaths in the range finding study, so a dose level of 25000 mg/kg bw was selected. Surviving male rats administered 25000 mg/kg bw in the LD50 test were weighed and observed during a 14-day recovery period, and then sacrificed.
- Doses:
- 25000 mg/kg bw
- No. of animals per sex per dose:
- 10 males
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 25 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/10
- Clinical signs:
- other: congestion and slight weight loss in one rat
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) in the rat is greater than 25000 mg/kg bw.
- Executive summary:
PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) has very low toxicity when administered orally to young adult Crl : CD male rats in single doses. Its LD50 is greater than 25000 mg/kg bw, the maximum feasible dose. There was no mortality, and the only clinical signs observed were congestion and slight weight loss in one rat (out of ten on test).
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