Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other:
Principles of method if other than guideline:
No guideline available
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3,4,4,5,5,6,6,6-nonafluorohexene
EC Number:
243-053-7
EC Name:
3,3,4,4,5,5,6,6,6-nonafluorohexene
Cas Number:
19430-93-4
Molecular formula:
C6H3F9
IUPAC Name:
3,3,4,4,5,5,6,6,6-nonafluorohex-1-ene
Test material form:
other: liquid
Details on test material:
Purity 99.0%
Impurities present:
3,3,3,4,4-pentafluoro-1-butene = 0.87%
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octene = 0.08%
1,1,1,2,2,3,3,4,4-nonafluoro-4-iodobutane = 0.004%

Test animals

Species:
rat
Strain:
other: Cr1 : CD
Sex:
male
Details on test animals or test system and environmental conditions:
Young adult Crl : CD rats with average bodyweight of 242g.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
The test material, which was used as received, was administered by intragastric intubation in single doses to a group of 10 young adult Cr1 : CD ® male rats. A range finding study was first conducted in the range 670 - 25000 mg/kg bw to determine the initial dose level for the LD50 test. There were no deaths in the range finding study, so a dose level of 25000 mg/kg bw was selected. Surviving male rats administered 25000 mg/kg bw in the LD50 test were weighed and observed during a 14-day recovery period, and then sacrificed.
Doses:
25000 mg/kg bw
No. of animals per sex per dose:
10 males

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 25 000 mg/kg bw
Based on:
test mat.
Mortality:
0/10
Clinical signs:
other: congestion and slight weight loss in one rat

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 of PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) in the rat is greater than 25000 mg/kg bw.
Executive summary:

PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) has very low toxicity when administered orally to young adult Crl : CD male rats in single doses. Its LD50 is greater than 25000 mg/kg bw, the maximum feasible dose. There was no mortality, and the only clinical signs observed were congestion and slight weight loss in one rat (out of ten on test).