Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only a secondary literature with very few information on the study design and on the results.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- GLP compliance:
- no
- Remarks:
- study performed before GLP establishment
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
- Details on test material:
- Data from handbook, no specific composition is available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A single application of fluoroacids to the skin of rabbits produced a marked irritant and caustic action to the products with formation of a dry ulcer extending as far as the muscular layer, without however becoming infected, followed by slow healing of the ulcer without moist granulations, with the formation of a soft delicate scar that was attached to the underlying tissue.
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