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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only a secondary literature with very few information on the study design and on the results.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

GLP compliance:
no
Remarks:
study performed before GLP establishment

Test material

Constituent 1
Chemical structure
Reference substance name:
Trifluoroacetic acid
EC Number:
200-929-3
EC Name:
Trifluoroacetic acid
Cas Number:
76-05-1
Molecular formula:
C2HF3O2
IUPAC Name:
trifluoroacetic acid
Details on test material:
Data from handbook, no specific composition is available.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified

Results and discussion

Applicant's summary and conclusion

Executive summary:

A single application of fluoroacids to the skin of rabbits produced a marked irritant and caustic action to the products with formation of a dry ulcer extending as far as the muscular layer, without however becoming infected, followed by slow healing of the ulcer without moist granulations, with the formation of a soft delicate scar that was attached to the underlying tissue.