Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Epidemiological data

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Administrative data

epidemiological data
Adequacy of study:
other information
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a secondary literature on the effects of anesthetics on reproduction and development in human

Data source

Reference Type:
review article or handbook

Materials and methods

Results and discussion

Applicant's summary and conclusion

Executive summary:

This review summarized the results of epidemiologic studies that assessed the adverse reproductive and developmental effects of anesthetic exposure on the pregnant surgical patient and the occupationally exposed female and male health care worker.

There is evidence in some of the studies of an increased rate of spontaneous abortion and fetal and perinatal mortality. These associations appear to be dependent on a number of factors that are not uniformly related to anesthesia alone.

But the epidemiologic evidence is too weak to conclude that there is a causal association between anesthetic exposure and adverse reproductive and developmental outcomes.

As this review deals only with anesthetic in a general manner, this publication was not consider in the toxicity assessment.