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EC number: 200-929-3 | CAS number: 76-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Storage stability and reactivity towards container material
Administrative data
- Endpoint:
- storage stability and reactivity towards container material
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- ALLOY TESTING AND SELECTION FOR A NOVEL CHLOROSULFONIC ACID ENVIRONMENT
- Author:
- John Flahive, Don Korte and Bruce Nacker
- Reference Type:
- other company data
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- During the scale-up of a new active pharmaceutical ingredient (API), materials of construction issues were of high importance due to the extremely aggressive nature of the reaction mixture and the corrosive gases produced as transient species during the reaction. In the early stages of technology transfer of this process from R&D to manufacturing, existing materials of construction of critical plant equipment had to be evaluated for chemical compatibility.
To ensure compatibility, extensive lab corrosion testing was performed on various corrosion-resistant materials, including glass, nickel alloys, tantalum, zirconium, and titanium, for this challenging application. Due to the complexity of the reaction mixture, the literature survey was utilized as a starting point to
determine which materials might be good candidates for this extremely corrosive service. TFA results were found and are reported in the present summary. - GLP compliance:
- no
Test material
- Reference substance name:
- TFA
- IUPAC Name:
- TFA
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
- Test material form:
- not specified
Constituent 1
Constituent 2
Results and discussion
- Results:
- TFA with less than 0.1% water is not corrosive to aluminum, nickel, monel, steels and higher alloys (see below). It can also be handled in glass and plastics such as polyethylene, polypropylene, PTFE, PCTFE and others, but it reacts with oxygen-containing plastics. Typically, TFA is shipped in polyethylene carboys, lined drums or larger stainless steel containers.
Corrosion Rates for Various Metals in TFA:
- Nickel : 0.4 Mils/Year
- Monel(TM) : 0.7 Mils/Year
- SS304 : 1 Mils/Year
- SS316 : 0.07 Mils/Year
- Carpenter 20 : 0.06 Mils/Year
- Inconel(TM) : 0.4 Mils/Year
- Aluminium : 0.03 Mils/Year
- Copper : 5 Mils/Year
Source : The vendor, Halocarbon Products Corporation, supplied corrosion data on TFA
Applicant's summary and conclusion
- Conclusions:
- TFA with less than 0.1% water is not corrosive to aluminum, nickel, monel, steels and higher alloys.
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