Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-929-3 | CAS number: 76-05-1
Storage stability and reactivity towards container material
Administrative data
- Endpoint:
- storage stability and reactivity towards container material
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- ALLOY TESTING AND SELECTION FOR A NOVEL CHLOROSULFONIC ACID ENVIRONMENT
- Author:
- John Flahive, Don Korte and Bruce Nacker
- Reference Type:
- other company data
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- During the scale-up of a new active pharmaceutical ingredient (API), materials of construction issues were of high importance due to the extremely aggressive nature of the reaction mixture and the corrosive gases produced as transient species during the reaction. In the early stages of technology transfer of this process from R&D to manufacturing, existing materials of construction of critical plant equipment had to be evaluated for chemical compatibility.
To ensure compatibility, extensive lab corrosion testing was performed on various corrosion-resistant materials, including glass, nickel alloys, tantalum, zirconium, and titanium, for this challenging application. Due to the complexity of the reaction mixture, the literature survey was utilized as a starting point to
determine which materials might be good candidates for this extremely corrosive service. TFA results were found and are reported in the present summary. - GLP compliance:
- no
Test material
- Reference substance name:
- TFA
- IUPAC Name:
- TFA
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
- Test material form:
- not specified
Constituent 1
Constituent 2
Results and discussion
- Results:
- TFA with less than 0.1% water is not corrosive to aluminum, nickel, monel, steels and higher alloys (see below). It can also be handled in glass and plastics such as polyethylene, polypropylene, PTFE, PCTFE and others, but it reacts with oxygen-containing plastics. Typically, TFA is shipped in polyethylene carboys, lined drums or larger stainless steel containers.
Corrosion Rates for Various Metals in TFA:
- Nickel : 0.4 Mils/Year
- Monel(TM) : 0.7 Mils/Year
- SS304 : 1 Mils/Year
- SS316 : 0.07 Mils/Year
- Carpenter 20 : 0.06 Mils/Year
- Inconel(TM) : 0.4 Mils/Year
- Aluminium : 0.03 Mils/Year
- Copper : 5 Mils/Year
Source : The vendor, Halocarbon Products Corporation, supplied corrosion data on TFA
Applicant's summary and conclusion
- Conclusions:
- TFA with less than 0.1% water is not corrosive to aluminum, nickel, monel, steels and higher alloys.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
